Vibhavari pradhan biography templates
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ABSTRACT
- Objective
Huntington’s disease (HD) is a genetic neurodegenerative disease that is caused by abnormal CAG expansion. Altered microRNA (miRNA) expression also causes abnormal gene regulation in this neurodegenerative disease. The delivery of abnormally downregulated miRNAs might restore normal gene regulation and have a therapeutic effect.
- Methods
We developed an exosome-based delivery method to treat this neurodegenerative disease. miR, one of the key miRNAs that is repressed in HD, was stably overexpressed in a stable cell line. Exosomes were then harvested from these cells using an optimized protocol. The exosomes (Exo) exhibited a high level of miR expression and were taken up by recipient cells.
- Results
When Exo was injected into the striatum of R6/2 transgenic HD mice, expression of the target gene, RE1-Silencing Transcription Factor, was reduced. However, Exo treatment did not produce significant behavioral improvement.
- Conclusion
This study serves as a proof of concept for exosome-based delivery of miRNA in neurodegenerative diseases.
- Keywords: Huntington’s disease; microRNA; R6/2; miR; exosome
Huntington’s disease (HD) is a genetic neurodegenerative disease that is caused by the abnormal expansion of CAG repeats in the gene encod
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Vibhavari Pradhan
Vaibhavari Pradhan is an Indian actress who has worked in Astharoopa Jai Vaibhavlakshmi Maata in It is the story about a devotee of Devi Maa, Sheela. sheela lives with her husband and younger brother, Sanjay. They are poor, but Sheela takes a loan from the head of the Village Subhan Rao so that Sanjay can go Abroad for his higher studies and become a doctor. Subhan Rao gives her the loan of Fifteen Lakhs rupees, which needs to be returned with interest and also with one condition that Sanjay will marry Subhan Rao's daughter, Gauri. But When Sanjay returns from Abroad, he tells his brother that he is in love with wealthy Naina. Then Shankar informs Shuban about His brother's love, and Sanjay wants permission to get marry Naina. Then Sanjay refuses to pay any loan and leaves the village. Subhan insults Sheela and Shankar and also snatch their house from them. Then Sheela prays Devi Maa to helping them. What happens next is the rest of the story?
Vaibhavari Pradhan was born and brought up in Mumbai. She is fluent in Marathi, Hindi and English. She also worked in Star Plus’s longest aired TV series Yeh Rishta Kya Kehlata Hai. This soap opera stars Shivangi Joshi, Mohsin Khan, Hina Khan and Karan Mehra. It launched at Rambagh Circle, Jaipur in Janua